diff --git a/configs/tfm_mbedcrypto_config_profile_medium.h b/configs/tfm_mbedcrypto_config_profile_medium.h
index b581f1f62..41e3afe27 100644
--- a/configs/tfm_mbedcrypto_config_profile_medium.h
+++ b/configs/tfm_mbedcrypto_config_profile_medium.h
@@ -407,6 +407,39 @@
  */
 #define MBEDTLS_HKDF_C /* Used for HUK deriviation */
 
+/**
+ * \def MBEDTLS_MD_C
+ *
+ * Enable the generic layer for message digest (hashing) and HMAC.
+ *
+ * Requires: one of: MBEDTLS_MD5_C, MBEDTLS_RIPEMD160_C, MBEDTLS_SHA1_C,
+ *                   MBEDTLS_SHA224_C, MBEDTLS_SHA256_C, MBEDTLS_SHA384_C,
+ *                   MBEDTLS_SHA512_C, or MBEDTLS_PSA_CRYPTO_C with at least
+ *                   one hash.
+ * Module:  library/md.c
+ * Caller:  library/constant_time.c
+ *          library/ecdsa.c
+ *          library/ecjpake.c
+ *          library/hkdf.c
+ *          library/hmac_drbg.c
+ *          library/pk.c
+ *          library/pkcs5.c
+ *          library/pkcs12.c
+ *          library/psa_crypto_ecp.c
+ *          library/psa_crypto_rsa.c
+ *          library/rsa.c
+ *          library/ssl_cookie.c
+ *          library/ssl_msg.c
+ *          library/ssl_tls.c
+ *          library/x509.c
+ *          library/x509_crt.c
+ *          library/x509write_crt.c
+ *          library/x509write_csr.c
+ *
+ * Uncomment to enable generic message digest wrappers.
+ */
+#define MBEDTLS_MD_C
+
 /**
  * \def MBEDTLS_MEMORY_BUFFER_ALLOC_C
  *