diff --git a/tests/scripts/depends.py b/tests/scripts/depends.py
index ce7fee65c..8baa8f3af 100755
--- a/tests/scripts/depends.py
+++ b/tests/scripts/depends.py
@@ -146,6 +146,8 @@ derived."""
     # Turn off options that are not relevant to the tests and slow them down.
     run_config_py(options, ['full'])
     run_config_py(options, ['unset', 'MBEDTLS_TEST_HOOKS'])
+    if options.unset_use_psa:
+        run_config_py(options, ['unset', 'MBEDTLS_USE_PSA_CRYPTO'])
 
 def collect_config_symbols(options):
     """Read the list of settings from mbedtls_config.h.
@@ -534,6 +536,9 @@ def main():
         parser.add_argument('--make-command', metavar='CMD',
                             help='Command to run instead of make (e.g. gmake)',
                             action='store', default='make')
+        parser.add_argument('--unset-use-psa',
+                            help='Unset MBEDTLS_USE_PSA_CRYPTO before any test',
+                            action='store_true', dest='unset_use_psa')
         parser.add_argument('tasks', metavar='TASKS', nargs='*',
                             help='The domain(s) or job(s) to test (default: all).',
                             default=True)