diff --git a/src/yuzu/configuration/configuration_shared.cpp b/src/yuzu/configuration/configuration_shared.cpp
index 97fb664bf2..ac42cc7fc2 100644
--- a/src/yuzu/configuration/configuration_shared.cpp
+++ b/src/yuzu/configuration/configuration_shared.cpp
@@ -92,3 +92,13 @@ void ConfigurationShared::InsertGlobalItem(QComboBox* combobox, int global_index
     combobox->insertItem(ConfigurationShared::USE_GLOBAL_INDEX, use_global_text);
     combobox->insertSeparator(ConfigurationShared::USE_GLOBAL_SEPARATOR_INDEX);
 }
+
+int ConfigurationShared::GetComboboxIndex(int global_setting_index, const QComboBox* combobox) {
+    if (Settings::IsConfiguringGlobal()) {
+        return combobox->currentIndex();
+    }
+    if (combobox->currentIndex() == ConfigurationShared::USE_GLOBAL_INDEX) {
+        return global_setting_index;
+    }
+    return combobox->currentIndex() - ConfigurationShared::USE_GLOBAL_OFFSET;
+}
diff --git a/src/yuzu/configuration/configuration_shared.h b/src/yuzu/configuration/configuration_shared.h
index e597dcdb5b..04c88758c6 100644
--- a/src/yuzu/configuration/configuration_shared.h
+++ b/src/yuzu/configuration/configuration_shared.h
@@ -69,4 +69,7 @@ void SetColoredComboBox(QComboBox* combobox, QWidget* target, int global);
 // Adds the "Use Global Configuration" selection and separator to the beginning of a QComboBox
 void InsertGlobalItem(QComboBox* combobox, int global_index);
 
+// Returns the correct index of a QComboBox taking into account global configuration
+int GetComboboxIndex(int global_setting_index, const QComboBox* combobox);
+
 } // namespace ConfigurationShared
diff --git a/src/yuzu/configuration/configure_system.cpp b/src/yuzu/configuration/configure_system.cpp
index 94049f2f44..9ea4c02da9 100644
--- a/src/yuzu/configuration/configure_system.cpp
+++ b/src/yuzu/configuration/configure_system.cpp
@@ -31,6 +31,9 @@ constexpr std::array<u32, 7> LOCALE_BLOCKLIST{
 };
 
 static bool IsValidLocale(u32 region_index, u32 language_index) {
+    if (region_index >= LOCALE_BLOCKLIST.size()) {
+        return false;
+    }
     return ((LOCALE_BLOCKLIST.at(region_index) >> language_index) & 1) == 0;
 }
 
@@ -55,8 +58,11 @@ ConfigureSystem::ConfigureSystem(Core::System& system_, QWidget* parent)
     });
 
     const auto locale_check = [this](int index) {
-        const bool valid_locale =
-            IsValidLocale(ui->combo_region->currentIndex(), ui->combo_language->currentIndex());
+        const auto region_index = ConfigurationShared::GetComboboxIndex(
+            Settings::values.region_index.GetValue(true), ui->combo_region);
+        const auto language_index = ConfigurationShared::GetComboboxIndex(
+            Settings::values.language_index.GetValue(true), ui->combo_language);
+        const bool valid_locale = IsValidLocale(region_index, language_index);
         ui->label_warn_invalid_locale->setVisible(!valid_locale);
         if (!valid_locale) {
             ui->label_warn_invalid_locale->setText(
diff --git a/src/yuzu/configuration/configure_system.h b/src/yuzu/configuration/configure_system.h
index 8f02880a7f..a7f0862581 100644
--- a/src/yuzu/configuration/configure_system.h
+++ b/src/yuzu/configuration/configure_system.h
@@ -42,13 +42,7 @@ private:
     std::unique_ptr<Ui::ConfigureSystem> ui;
     bool enabled = false;
 
-    int language_index = 0;
-    int region_index = 0;
-    int time_zone_index = 0;
-    int sound_index = 0;
-
     ConfigurationShared::CheckState use_rng_seed;
-    ConfigurationShared::CheckState use_custom_rtc;
 
     Core::System& system;
 };